Endocrine Abstracts

Patients with hypopituitarism and untreated growth hormone (GH) deficiency have excess mortality. GH replacement therapy (GHRT) has many beneficial effects, but its impact on mortality has not been proven and there are still safety concerns regarding the potential cancer risk. We have therefore studied the mortality in non-functioning pituitary adenoma (NFPA) patients with and without GHRT. Only patients with NFPA were studied in order to eliminate the influence of the aetiolo...

Growth hormone (GH) and insulin like growth factor 1 (IGF-I) modulate and stimulate angiogenesis and endothelial function. Excess of GH, as in acromegaly, is associated with cardiovascular morbidity and mortality, which is reversible after normalization of IGF-I and GH. Diabetes mellitus (DM) is a common comorbidity in acromegaly, but the prevalence of diabetes retinopathy in patients with acromegaly is unknown. Also, the roles of GH and IGF-I in diabetes retinopathy are not f...

Context: Abdominally obese individuals have relative hyposomatotropism, elevated serum markers of inflammation, and increased risk of cardiovascular disease (CVD).Objective: The aim was to study the effect of GH treatment on serum levels of inflammatory markers and vascular adhesion molecules in postmenopausal women with abdominal obesity.Design: Forty postmenopausal women aged 51–63 yrs with abdominal obesity received GH (0.6...